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Role of Rsp5 ubiquitin ligase in biogenesis of rRNA, mRNA and tRNA in yeast

Domańska, Anna and Kaminska, Joanna (2015) Role of Rsp5 ubiquitin ligase in biogenesis of rRNA, mRNA and tRNA in yeast. RNA Biology . ISSN 1099-0123 (In Press)

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Official URL: http://www.tandfonline.com/doi/abs/10.1080/1547628...


Rsp5 ubiquitin ligase is required for ubiquitination of a wide variety of proteins involved in essential processes. Rsp5 was shown to be involved in regulation of lipid biosynthesis, intracellular trafficking of proteins, response to various stresses, and many other processes. In this article, we provide a comprehensive review of the nuclear and cytoplasmic functions of Rsp5 with a focus on biogenesis of different RNAs. We also briefly describe the participation of Rsp5 in the regulation of the RNA polymerase II complex, and its potential role in the regulation of other RNA polymerases. Moreover, we emphasize the function of Rsp5 in the coordination of the different steps of rRNA, mRNA and tRNA metabolism in the context of protein biosynthesis. Finally, we highlight the involvement of Rsp5 in controlling diverse cellular mechanisms at multiple levels and in adaptation of the cell to changing growth conditions.

Item Type:Article
Subjects:Q Science > Q Science (General)
Divisions:Department of Genetics
ID Code:1015
Deposited By: PhD Joanna Kamińska
Deposited On:18 Nov 2015 08:44
Last Modified:08 Mar 2018 15:33

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