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Total and high molecular weight adiponectin levels in the rat model of post-myocardial infarction heart failure.

Kalisz, Małgorzata and Baranowska, Bogusława and Wolińska-Witort, Ewa and Mączewski, Michał and Mackiewicz, Urszula and Tułacz, Dorota and Gora, Monika and Martyńska, Lidia and Bik, Wojciech (2015) Total and high molecular weight adiponectin levels in the rat model of post-myocardial infarction heart failure. Journal of Physiology and Pharmacology, 66 (6). pp. 673-680. ISSN 0867-5910

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Abstract

Adiponectin is a protein secreted primarily by adipose tissue. It has been suggested that adiponectin plays a protective role in the early phase following myocardial infarction. Our primary aim was to investigate the effects of post-myocardial infarction heart failure well-characterized by left ventricular hemodynamic parameters on the total and high molecular weight adiponectin concentrations in plasma, fat and cardiac tissue. Eight weeks after myocardial infarction or sham operation, total and high molecular weight adiponectin concentrations in plasma, fat, and cardiac tissues were assayed in rats. In addition, hemodynamic parameters and expression of the genes encoding atrial natriuretic peptide and brain natriuretic peptide in left ventricle were evaluated. Atrial natriuretic peptide and brain natriuretic peptide mRNA levels in left ventricle tissue were higher in rats with myocardial infarction-induced heart failure compared with the controls. Similarly, total adiponectin concentration was increased in left ventricle (but not in right ventricle) in rats with postmyocardial infarction heart failure. In contrast, adiponectin levels in plasma and cardiac adipose tissue in rats with postmyocardial infarction heart failure were lower than in sham-operated animals. Furthermore, there were no significant differences in levels of high molecular weight adiponectin in plasma, cardiac tissue or adipose tissue between these two groups. We conclude that in the rat model of post-myocardial infarction heart failure, adiponectin level is increased in left ventricle tissue. This is accompanied by decreased adiponectin levels in plasma and cardiac adipose tissue.

Item Type:Article
Subjects:Q Science > QP Physiology
Divisions:Department of Genetics
ID Code:1022
Deposited By: dr Monika Góra
Deposited On:03 Dec 2015 09:14
Last Modified:03 Dec 2015 09:14

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