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Chlebowski, Aleksander and Tomecki, Rafał and Gas López, Maria Eugenia and Séraphin, Bertrand and Dziembowski, Andrzej (2010) CATALYTIC PROPERTIES OF THE EUKARYOTIC EXOSOME. In: RNA exosome. Advances in Experimental Medicine and Biology (702). Landes Bioscience and Springer Science+Business Media. ISBN 978-1-4419-7840-0



The eukaryotic exosome complex is built around the backbone of a 9‑subunit ring similar to phosporolytic ribonucleases such as RNase PH and polynucleotide phosphorylase (PNPase). Unlike those enzymes, the ring is devoid of any detectable catalytic activities, with the possible exception of the plant version of the complex. Instead, the essential RNA decay capability is supplied by associated hydrolytic ribonucleases belonging to the Dis3 and Rrp6 families. Dis3 proteins are endowed with two different activities: the long known processive 3′‑5′ exonucleolytic one and the recently discovered endonucleolytic one. Rrp6 proteins are distributive exonucleases. This chapter will review the current knowledge about the catalytic properties of theses nucleases and their interplay within the exosome holocomplex.

Item Type:Book Section
Subjects:Q Science > QH Natural history > QH301 Biology
Divisions:Department of Biophysics
ID Code:132
Deposited By: Rafal Tomecki
Deposited On:05 May 2011 20:40
Last Modified:28 Mar 2012 20:35

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