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Fungal lifestyle reflected in serine protease repertoire

Muszewska, Anna and Stepniewska-Dziubinska, Marta M. and Steczkiewicz, Kamil and Pawłowska, Julia and Dziedzic, Agata and Ginalski, Krzysztof (2017) Fungal lifestyle reflected in serine protease repertoire. Scientific Reports, 7 . ISSN 2045-2322

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Official URL: http://doi.org/10.1038/s41598-017-09644-w


Fungi are able to switch between different lifestyles in order to adapt to environmental changes. Their ecological strategy is connected to their secretome as fungi obtain nutrients by secreting hydrolytic enzymes to their surrounding and acquiring the digested molecules. We focus on fungal serine proteases (SPs), the phylogenetic distribution of which is barely described so far. In order to collect a complete set of fungal proteases, we searched over 600 fungal proteomes. Obtained results suggest that serine proteases are more ubiquitous than expected. From 54 SP families described in MEROPS Peptidase Database, 21 are present in fungi. Interestingly, 14 of them are also present in Metazoa and Viridiplantae – this suggests that, except one (S64), all fungal SP families evolved before plants and fungi diverged. Most representatives of sequenced eukaryotic lineages encode a set of 13–16 SP families. The number of SPs from each family varies among the analysed taxa. The most abundant are S8 proteases. In order to verify hypotheses linking lifestyle and expansions of particular SP, we performed statistical analyses and revealed previously undescribed associations. Here, we present a comprehensive evolutionary history of fungal SP families in the context of fungal ecology and fungal tree of life.

Item Type:Article
Subjects:Q Science > QH Natural history > QH301 Biology
Divisions:Department of Microbial Biochemistry
ID Code:1369
Deposited By: dr Anna Muszewska
Deposited On:23 Aug 2017 11:04
Last Modified:23 Aug 2017 11:04

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