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Diverse roles of Dpb2, the non-catalytic subunit of DNA polymerase ε

Dmowski, Michal and Fijalkowska, Iwona J. (2017) Diverse roles of Dpb2, the non-catalytic subunit of DNA polymerase ε. Current Genetics, 63 (6). pp. 983-987. ISSN 0172-8083

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Official URL: http://doi.org/10.1007/s00294-017-0706-7


Timely progression of living cells through the cell cycle is precisely regulated. This involves a series of phosphorylation events which are regulated by various cyclins, activated in coordination with the cell cycle progression. Phosphorylated proteins govern cell growth, division as well as duplication of the genetic material and transcriptional activation of genes involved in these processes. A subset of these tightly regulated genes, which depend on the MBF transcription factor and are mainly involved in DNA replication and cell division, is transiently activated at the transition from G1 to S phase. A Saccharomyces cerevisiae mutant in the Dpb2 non-catalytic subunit of DNA polymerase ε (Polε) demonstrates abnormalities in transcription of MBF-dependent genes even in normal growth conditions. It is, therefore, tempting to speculate that Dpb2 which, as described previously, participates in the early stages of DNA replication initiation, has an impact on the regulation of replication-related genes expression with possible implications for genomic stability.

Item Type:Article
Subjects:Q Science > QR Microbiology
Divisions:Laboratory of Mutagenesis and DNA Repair
ID Code:1421
Deposited By: dr Michał Dmowski
Deposited On:27 Nov 2017 08:35
Last Modified:27 Nov 2017 08:45

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