Mieczkowski, Adam and Trzybiński, Damian and Wilczek, Marcin and Psurski, Mateusz and Bagiński, Maciej and Bieszczad, Bartosz and Mroczkowska, Magdalena and Woźniak, Krzysztof (2017) (S)-2-(4-Chlorobenzoyl)-1,2,3,4-tetrahydrobenzo[e]pyrazino[1,2-a][1,4]diazepine-6,12(11H,12aH)-dione—Synthesis and Crystallographic Studies. Molbank, 2017 (4). M964. ISSN 1422-8599
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Official URL: http://doi.org/10.3390/M964
Abstract
(S)-2-(4-Chlorobenzoyl)-1,2,3,4-tetrahydrobenzo[e]pyrazino[1,2-a][1,4]diazepine-6,12(11H, 12aH)-dione was obtained in a three-step, one-pot synthesis, starting from optically pure (S)-2-piperazine carboxylic acid dihydrochloride. Selective acylation of the b-nitrogen atom followed by condensation with isatoic anhydride and cyclization with HATU/DIPEA to a seven-member benzodiazepine ring, led to the tricyclic benzodiazepine derivative. Crystallographic studies and initial biological screening were performed for the title compound.
| Item Type: | Article |
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| Subjects: | Q Science > QD Chemistry |
| Divisions: | Department of Biophysics |
| ID Code: | 1441 |
| Deposited By: | Dr Adam Mieczkowski |
| Deposited On: | 06 Dec 2017 10:54 |
| Last Modified: | 06 Dec 2017 10:54 |
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