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(S)-2-(4-Chlorobenzoyl)-1,2,3,4-tetrahydrobenzo[e]pyrazino[1,2-a][1,4]diazepine-6,12(11H,12aH)-dione—Synthesis and Crystallographic Studies

Mieczkowski, Adam and Trzybiński, Damian and Wilczek, Marcin and Psurski, Mateusz and Bagiński, Maciej and Bieszczad, Bartosz and Mroczkowska, Magdalena and Woźniak, Krzysztof (2017) (S)-2-(4-Chlorobenzoyl)-1,2,3,4-tetrahydrobenzo[e]pyrazino[1,2-a][1,4]diazepine-6,12(11H,12aH)-dione—Synthesis and Crystallographic Studies. Molbank, 2017 (4). M964. ISSN 1422-8599


Official URL: http://doi.org/10.3390/M964


(S)-2-(4-Chlorobenzoyl)-1,2,3,4-tetrahydrobenzo[e]pyrazino[1,2-a][1,4]diazepine-6,12(11H, 12aH)-dione was obtained in a three-step, one-pot synthesis, starting from optically pure (S)-2-piperazine carboxylic acid dihydrochloride. Selective acylation of the b-nitrogen atom followed by condensation with isatoic anhydride and cyclization with HATU/DIPEA to a seven-member benzodiazepine ring, led to the tricyclic benzodiazepine derivative. Crystallographic studies and initial biological screening were performed for the title compound.

Item Type:Article
Subjects:Q Science > QD Chemistry
Divisions:Department of Biophysics
ID Code:1441
Deposited By: Dr Adam Mieczkowski
Deposited On:06 Dec 2017 10:54
Last Modified:06 Dec 2017 10:54

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