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Boron Cluster Modification with Antiviral, Anticancer, and Modulation of Purinergic Receptors' Activities Based on the Nucleoside Structure

Adamska-Bartlomiejczyk, Anna and Bednarska, Katarzyna and Bialek-Pietras, Magdalena and Kilianska, Zofia M and Mieczkowski, Adam and Olejniczak, Agnieszka B and Paradowska, Edyta and Studzinska, Miroslawa and Sulkowska, Zofia and Zolnierczyk, Jolanta D. and Leśnikowski, Zbigniew J (2018) Boron Cluster Modification with Antiviral, Anticancer, and Modulation of Purinergic Receptors' Activities Based on the Nucleoside Structure. In: Boron-Based Compounds Potential and Emerging Applications in Medicine. Wiley, pp. 20-34. ISBN 978-1-119-27555-8

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Official URL: https://www.wiley.com/en-pl/Boron+Based+Compounds:...

Abstract

Nucleoside analogs have been in clinical use for several decades and have become cornerstones of treatment for patients with cancer or viral infections [1,2]. This is complemented with nucleoside antibiotics, a large family of microbial natural products and synthetic derivatives derived from nucleosides and nucleotides [3]. The approval of several new nucleoside drugs over the past decade demonstrates that this class of compounds still possesses strong potential [1,2]. The potential of nucleosides in chemotherapy is enhanced by development of new chemistries for nucleoside modification, better understanding of molecular mechanisms of nucleoside drugs’ actions [4], and pro‐drug technology [5,6]. One of the new developments in the medicinal chemistry of nucleosides is nucleoside derivatives comprising a boron component [7]. The boron part can contain a single boron atom [8] or several boron atoms in the form of a boron cluster (Figure 1.2.1) [9–11].

Item Type:Book Section
Subjects:R Medicine > RM Therapeutics. Pharmacology
Divisions:Department of Biophysics
ID Code:1533
Deposited By: Dr Adam Mieczkowski
Deposited On:29 May 2018 07:26
Last Modified:29 May 2018 09:26

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