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Circulating miR-30a-5p as a prognostic biomarker of left ventricular dysfunction after acute myocardial infarction

Maciejak, Agata and Kostarska-Srokosz, Edyta and Gierlak, Wlodzimierz and Dluzniewski, Miroslaw and Kuch, Marek and Marchel, Michal and Opolski, Grzegorz and Kiliszek, Marek and Matlak, Krzysztof and Dobrzycki, Slawomir and Lukasik, Anna and Segiet, Agnieszka and Sygitowicz, Grażyna and Sitkiewicz, Dariusz and Gora, Monika and Burzynska, Beata (2018) Circulating miR-30a-5p as a prognostic biomarker of left ventricular dysfunction after acute myocardial infarction. Scientific Reports, 8 (1). ISSN 2045-2322

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Official URL: http://doi.org/10.1038/s41598-018-28118-1

Abstract

Left ventricular (LV) dysfunction after acute myocardial infarction (AMI) is associated with an increased risk of heart failure (HF) development. Diverse microRNAs (miRNAs) have been shown to appear in the bloodstream following various cardiovascular events. The aim of this study was to identify prognostic miRNAs associated with LV dysfunction following AMI. Patients were divided into subgroups comprising patients who developed or not LV dysfunction within six months of the infarction. miRNA profiles were determined in plasma and serum samples of the patients on the first day of AMI. Levels of 14 plasma miRNAs and 16 serum miRNAs were significantly different in samples from AMI patients who later developed LV dysfunction compared to those who did not. Two miRNAs were up-regulated in both types of material. Validation in an independent group of patients, using droplet digital PCR (ddPCR) confirmed that miR-30a-5p was significantly elevated on admission in those patients who developed LV dysfunction and HF symptoms six months after AMI. A bioinformatics analysis indicated that miR-30a-5p may regulate genes involved in cardiovascular pathogenesis. This study demonstrates, for the first time, a prognostic value of circulating miR-30a-5p and its association with LV dysfunction and symptoms of HF after AMI.

Item Type:Article
Subjects:Q Science > QH Natural history > QH426 Genetics
Divisions:Department of Genetics
ID Code:1637
Deposited By: dr Monika Góra
Deposited On:29 Nov 2018 10:07
Last Modified:29 Nov 2018 10:07

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