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Abnormal sphingolipid world in inflammation specific for lysosomal storage diseases and skin disorders.

Moskot, Marta and Bocheńska, Katarzyna and Jakóbkiewicz-Banecka, Joanna and Banecki, Bogdan and Gabig-Cimińska, Magdalena (2018) Abnormal sphingolipid world in inflammation specific for lysosomal storage diseases and skin disorders. International Journal of Molecular Sciences, 19 (1). ISSN 1422-0067

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Official URL: https://www.mdpi.com/1422-0067/19/1/247

Abstract

Research in recent years has shown that sphingolipids are essential signalling molecules for the proper biological and structural functioning of cells. Long-term studies on the metabolism of sphingolipids have provided evidence for their role in the pathogenesis of a number of diseases. As many inflammatory diseases, such as lysosomal storage disorders and some dermatologic diseases, including psoriasis, atopic dermatitis and ichthyoses, are associated with the altered composition and metabolism of sphingolipids, more studies precisely determining the responsibilities of these compounds for disease states are required to develop novel pharmacological treatment opportunities. It is worth emphasizing that knowledge from the study of inflammatory metabolic diseases and especially the possibility of their treatment may lead to insight into related metabolic pathways, including those involved in the formation of the epidermal barrier and providing new approaches towards workable therapies.

Item Type:Article
Subjects:Q Science > Q Science (General)
Divisions:Laboratory of Molecular Biology (in Gdansk)
ID Code:1688
Deposited By: Prof. Magdalena Gabig-Cimińska
Deposited On:26 Feb 2019 08:28
Last Modified:26 Feb 2019 08:28

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