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Mitochondrial stress-dependent regulation of cellular protein synthesis

Topf, Ulrike and Uszczynska-Ratajczak, Barbara and Chacinska, Agnieszka (2019) Mitochondrial stress-dependent regulation of cellular protein synthesis. Journal of Cell Science, 132 (8). jcs226258. ISSN 0021-9533


Official URL: http://doi.org/10.1242/jcs.226258


The production of newly synthesized proteins is vital for all cellular functions and is a determinant of cell growth and proliferation. The synthesis of polypeptide chains from mRNA molecules requires sophisticated machineries and mechanisms that need to be tightly regulated, and adjustable to current needs of the cell. Failures in the regulation of translation contribute to the loss of protein homeostasis, which can have deleterious effects on cellular function and organismal health. Unsurprisingly, the regulation of translation appears to be a crucial element in stress response mechanisms. This review provides an overview of mechanisms that modulate cytosolic protein synthesis upon cellular stress, with a focus on the attenuation of translation in response to mitochondrial stress. We then highlight links between mitochondrion-derived reactive oxygen species and the attenuation of reversible cytosolic translation through the oxidation of ribosomal proteins at their cysteine residues. We also discuss emerging concepts of how cellular mechanisms to stress are adapted, including the existence of alternative ribosomes and stress granules, and the regulation of co-translational import upon organelle stress.

Item Type:Article
Subjects:Q Science > Q Science (General)
Divisions:Department of Genetics
ID Code:1776
Deposited By: Dr hab. Ulrike Topf
Deposited On:15 Jun 2021 09:40
Last Modified:15 Jun 2021 09:40

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