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Candida albicans; exploring glycosylation pathway in the search of targets for antimicrobial agents and yeast to hyphae transition

Juchimiuk, Mateusz and Janik, Anna and Niewiadomska, Monika and Perlinska-Lenart, Urszula and Kruszewska, Joanna S. and Palamarczyk, Grazyna (2019) Candida albicans; exploring glycosylation pathway in the search of targets for antimicrobial agents and yeast to hyphae transition. Medical Research Archives, 7 (9).

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Official URL: https://journals.ke-i.org/index.php/mra/article/vi...

Abstract

Microbial cell wall is mostly synthesized by the glycosylated proteins with the distinct enzymatic activity. In this review we have concentrated on the description of the certain steps of glycosylation and their effect on the cell wall integrity and yeast to hyphae transition, the process enhancing the pathogenic properties of C.albicans. The glycoproteins play an invaluable role in C. albicans virulence and they modulate adhesive, invasive, morphogenetic and immune stimulating properties of the pathogen as well as its susceptibility to the antifungal agents. Therefore, understanding of C. albicans glycobiology might let us expand the arsenal in the war against fungal enemies. The early stages of N-, O-glycans and GPI-anchor synthesis requires dolichol - the lipid carrier of sugar residues. Diminished supply of dolichol causes series of defects in C. albicans cells, among which aberrant protein glycosylation is the most evident. Furthermore, the relations between the cell wall composition and integrity, resistance to some antifungal and cell wall disturbing agents and dolichol dependent glycosylation are observed. Moreover relevance of these reactions for the morphological differentiation of C.albicans is described.

Item Type:Article
Subjects:Q Science > Q Science (General)
Q Science > QH Natural history > QH301 Biology
Divisions:Laboratory of Fungal Glycobiology
ID Code:1794
Deposited By: prof dr hab Joanna S. Kruszewska
Deposited On:10 Dec 2019 15:39
Last Modified:10 Dec 2019 15:39

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