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Rules and Exceptions: The Role of Chromosomal ParB in DNA Segregation and Other Cellular Processes

Kawalek, Adam and Wawrzyniak, Paweł and Bartosik, Aneta A and Jagura-Burdzy, Grazyna (2020) Rules and Exceptions: The Role of Chromosomal ParB in DNA Segregation and Other Cellular Processes. Microorganisms, 8 (1). ISSN 2076-2607

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Official URL: https://www.mdpi.com/2076-2607/8/1/105

Abstract

Abstract: The segregation of newly replicated chromosomes in bacterial cells is a highly coordinated spatiotemporal process. In the majority of bacterial species, a tripartite ParAB-parS system, composed of an ATPase (ParA), a DNA-binding protein (ParB), and its target(s) parS sequence(s), facilitates the initial steps of chromosome partitioning. ParB nucleates around parS(s) located in the vicinity of newly replicated oriCs to form large nucleoprotein complexes, which are subsequently relocated by ParA to distal cellular compartments. In this review, we describe the role of ParB in various processes within bacterial cells, pointing out interspecies differences. We outline recent progress in understanding the ParB nucleoprotein complex formation and its role in DNA segregation, including ori positioning and anchoring, DNA condensation, and loading of the structural maintenance of chromosome (SMC) proteins. The auxiliary roles of ParBs in the control of chromosome replication initiation and cell division, as well as the regulation of gene expression, are discussed. Moreover, we catalog ParB interacting proteins. Overall, this work highlights how different bacterial species adapt the DNA partitioning ParAB-parS system to meet their specific requirements.

Item Type:Article
Uncontrolled Keywords:ParB; segrosome; chromosome segregation; cell division; gene expression regulation; partitioning proteins
Subjects:Q Science > QR Microbiology
Divisions:Department of Microbial Biochemistry
ID Code:1811
Deposited By: dr Adam Kawałek
Deposited On:20 Jan 2020 09:08
Last Modified:20 Jan 2020 09:08

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