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Formation of highly stable multinuclear AgnSn clusters in zinc fingers disrupts their structure and function

Kluska, Katarzyna and Peris-Díaz, Manuel D. and Płonka, Dawid and Moysa, Alexander and Dadlez, Michal and Deniaud, Aurélien and Bal, Wojciech and Krezel, Artur (2020) Formation of highly stable multinuclear AgnSn clusters in zinc fingers disrupts their structure and function. Chemical Communications, 56 (9). pp. 1329-1332. ISSN 1359-7345

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Official URL: http://doi.org/10.1039/c9cc09418k

Abstract

Silver (Ag(I)) binding to consensus zinc fingers (ZFs) causes Zn(II) release inducing a gradual disruption of the hydrophobic core, followed by an overall conformational change and formation of highly stable AgnSn clusters. A compact eight-membered Ag4S4 structure formed by a CCCC ZF is the first cluster example reported for a single biological molecule. Ag(I)-induced conformational changes of ZFs can, as a consequence, affect transcriptional regulation and other cellular processes.

Item Type:Article
Subjects:Q Science > Q Science (General)
ID Code:1823
Deposited By: PhD Alexander Moysa
Deposited On:03 Feb 2020 10:16
Last Modified:03 Feb 2020 10:16

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