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Antibacterial Peptide Nucleic Acids—Facts and Perspectives

Wojciechowska, Monika and Równicki, Marcin and Mieczkowski, Adam and Miszkiewicz, Joanna and Trylska, Joanna (2020) Antibacterial Peptide Nucleic Acids—Facts and Perspectives. Molecules, 25 (3). p. 559. ISSN 1420-3049

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Official URL: https://www.mdpi.com/1420-3049/25/3/559

Abstract

Antibiotic resistance is an escalating, worldwide problem. Due to excessive use of antibiotics, multidrug‐resistant bacteria have become a serious threat and a major global healthcare problem of the 21st century. This fact creates an urgent need for new and effective antimicrobials. The common strategies for antibiotic discovery are based on either modifying existing antibiotics or screening compound libraries, but these strategies have not been successful in recent decades. An alternative approach could be to use gene‐specific oligonucleotides, such as peptide nucleic acid (PNA) oligomers, that can specifically target any single pathogen. This approach broadens the range of potential targets to any gene with a known sequence in any bacterium, and could significantly reduce the time required to discover new antimicrobials or their redesign, if resistance arises. We review the potential of PNA as an antibacterial molecule. First, we describe the physicochemical properties of PNA and modifications of the PNA backbone and nucleobases. Second, we review the carriers used to transport PNA to bacterial cells. Furthermore, we discuss the PNA targets in antibacterial studies focusing on antisense PNA targeting bacterial mRNA and rRNA.

Item Type:Article
Uncontrolled Keywords:oligonucleotides; peptide nucleic acid (PNA); antibacterials; RNA; PNA transporters; conjugates; bacterial resistance
Subjects:Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
Divisions:Department of Biophysics
ID Code:1825
Deposited By: Dr Adam Mieczkowski
Deposited On:03 Feb 2020 09:55
Last Modified:03 Feb 2020 09:55

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