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Serum microRNA in patients undergoing atrial fibrillation ablation.

Kiliszek, Marek and Maciak, Karolina and Maciejak, Agata and Krzyżanowski, Krystian and Wierzbowski, Robert and Gora, Monika and Burzynska, Beata and Segiet, Agnieszka and Skrobowski, Andrzej (2020) Serum microRNA in patients undergoing atrial fibrillation ablation. Scientific Reports, 10 (1). p. 4424. ISSN 2045-2322


Official URL: https://www.nature.com/articles/s41598-020-61322-6


MicroRNAs mediate posttranscriptional gene regulation. The aim of the study was to find a microRNA predictor of successful atrial fibrillation (AF) ablation. A total of 109 patients undergoing first-time AF ablation were included. Nineteen patients were selected to undergo serum microRNA sequencing (study group). The sequencing data were used to select several microRNAs that correlated with 12-month recurrences after AF ablation. Those microRNAs were validated by digital droplet PCR in samples from remaining 90 patients. All patients underwent pulmonary vein isolation (RF ablation, contact force catheter, electroanatomical system). The endpoint of the study was the 12-month AF recurrence rate; the overall recurrence rate was 42.5%. In total, levels of 34 miRNAs were significantly different in sera from patients with AF recurrence compared to patients without AF recurrence. Six microRNAs (miR-183-5p, miR-182-5p, miR-32-5p, miR-107, miR-574-3p, and miR-144-3p) were validated in the whole group. Data from the validation group did not confirm the observations from the study group, as no significant differences were found between miRNAs serum levels in patients with and without recurrences 12 months after AF ablation.

Item Type:Article
Subjects:Q Science > Q Science (General)
ID Code:1868
Deposited By: dr Monika Góra
Deposited On:26 Mar 2020 12:23
Last Modified:26 Mar 2020 12:23

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