IBB PAS Repository

Dehydro-tocotrienol-β counteracts oxidative-stress-induced diabetes complications in db/db mice.

Dallner, Gustav and Bentinger, Magnus and Hussain, Shafaat and Sinha, Indranil and Yang, Jiangning and Schwank-Xu, Cheng and Zheng, Xiaowei and Swiezewska, Ewa and Brismar, Kerstin and Valladolid, Ismael and Tekle, Michael (2021) Dehydro-tocotrienol-β counteracts oxidative-stress-induced diabetes complications in db/db mice. Antioxidants, 10 (7).


Official URL: https://www.mdpi.com/2076-3921/10/7/1070


Hyperglycemia, hyperlipidemia, and adiposity are the main factors that cause inflammation in type 2 diabetes due to excessive ROS production, leading to late complications. To counteract the effects of increased free radical production, we searched for a compound with effective antioxidant properties that can induce coenzyme Q biosynthesis without affecting normal cellular functions.Tocotrienols are members of the vitamin E family, well-known as efficient antioxidants that are more effective than tocopherols. Deh-T3beta� is a modified form of the naturally occurring tocotrienol-beta�. The synthesis of this compound involves the sequential modification of geranylgeraniol. In this study, we investigated the effects of this compound in different experimental models of diabetes complications. Deh-T3beta� was found to possess multifaceted capacities. In addition to enhanced wound healing, deh-T3beta� improved kidney and liver functions, reduced liver steatosis, and improved heart recovery after ischemia and insulin sensitivity in adipose tissue in a mice model of type 2 diabetes. Deh-T3�beta exerts these positive effects in several organs of the diabetic mice without reducing the non-fasting blood glucose levels, suggesting that both its antioxidant properties and improvement in mitochondrial function are involved, which are central to reducing diabetes complications.

Item Type:Article
Subjects:Q Science > QH Natural history > QH301 Biology
Divisions:Department of Lipid Biochemistry
ID Code:2064
Deposited By: Ewa Swiezewska
Deposited On:22 Jul 2021 12:13
Last Modified:22 Jul 2021 12:13

Repository Staff Only: item control page