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Sequencing the Genomes of the First Terrestrial Fungal Lineages: What Have We Learned?

Gryganskyi, Andrii and Golan, Jacob and Muszewska, Anna and Idnurm, Alexander and Dolatabadi, Somayeh and Mondo, Stephen and Kutovenko, Vira and Kutovenko, Volodymyr and Gajdeczka, Michael and Anishchenko, Iryna M. and Pawłowska, Julia and Tran, Ngoc Vinh and Ebersberger, Ingo and Voigt, Kerstin and Wang, Yan and Chang, Ying and Pawłowska, Teresa and Heitman, Joseph and Vilgalys, Rytas and Bonito, Gregory and Benny, Gerald and Smith, Matthew and Reynolds, Nicole and James, Timothy and Grigoriev, Igor and Spatafora, Joseph and Stajich, Jason E. (2023) Sequencing the Genomes of the First Terrestrial Fungal Lineages: What Have We Learned? Microorganisms, 11 (7). ISSN 2076-2607

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Official URL: https://www.mdpi.com/2076-2607/11/7/1830


The first genome sequenced of a eukaryotic organism was for Saccharomyces cerevisiae, as reported in 1996, but it was more than 10 years before any of the zygomycete fungi, which are the early-diverging terrestrial fungi currently placed in the phyla Mucoromycota and Zoopagomycota, were sequenced. The genome for Rhizopus delemar was completed in 2008; currently, more than 1000 zygomycete genomes have been sequenced. Genomic data from these early-diverging terrestrial fungi revealed deep phylogenetic separation of the two major clades—primarily plant—associated saprotrophic and mycorrhizal Mucoromycota versus the primarily mycoparasitic or animal-associated parasites and commensals in the Zoopagomycota. Genomic studies provide many valuable insights into how these fungi evolved in response to the challenges of living on land, including adaptations to sensing light and gravity, development of hyphal growth, and co-existence with the first terrestrial plants. Genome sequence data have facilitated studies of genome architecture, including a history of genome duplications and horizontal gene transfer events, distribution and organization of mating type loci, rDNA genes and transposable elements, methylation processes, and genes useful for various industrial applications. Pathogenicity genes and specialized secondary metabolites have also been detected in soil saprobes and pathogenic fungi. Novel endosymbiotic bacteria and viruses have been discovered during several zygomycete genome projects. Overall, genomic information has helped to resolve a plethora of research questions, from the placement of zygomycetes on the evolutionary tree of life and in natural ecosystems, to the applied biotechnological and medical questions.

Item Type:Article
Subjects:Q Science > QH Natural history > QH301 Biology
Q Science > QR Microbiology
Divisions:Department of Microbial Biochemistry
ID Code:2310
Deposited By: dr Anna Muszewska
Deposited On:07 Sep 2023 06:57
Last Modified:07 Sep 2023 07:49

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