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Designing multi-target-directed flavonoids: a strategic approach to Alzheimer's disease

Park, Seongmin and Kim, Mingeun and Lin, Yuxi and Hong, Mannkyu and Nam, Geewoo and Mieczkowski, Adam and Kardos, Jozsef and Lee, Young-Ho and Lim, Mi Hee (2023) Designing multi-target-directed flavonoids: a strategic approach to Alzheimer's disease. Chemical Science, 14 (35). pp. 9293-9305.


Official URL: https://pubs.rsc.org/en/content/articlelanding/202...


The underlying causes of Alzheimer's disease (AD) remain a mystery, with multiple pathological components, including oxidative stress, acetylcholinesterase, amyloid-b, and metal ions, all playing a role. Here we report a strategic approach to designing flavonoids that can effectively tackle multiple pathological elements involved in AD. Our systematic investigations revealed key structural features for flavonoids to simultaneously target and regulate pathogenic targets. Our findings led to the development of a highly promising flavonoid that exhibits a range of functions, based on a complete structure–activity relationship analysis. Furthermore, our mechanistic studies confirmed that this flavonoid's versatile reactivities are driven by its redox potential and direct interactions with pathogenic factors. This work highlights the potential of multi-target-directed flavonoids as a novel solution in the fight against AD.

Item Type:Article
Subjects:Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
Divisions:Department of Biophysics
ID Code:2324
Deposited By: Dr Adam Mieczkowski
Deposited On:15 Sep 2023 07:14
Last Modified:15 Sep 2023 07:14

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