Stępień, Piotr P. and Bohr, Vilhelm A and Kulikowicz, Tomasz (2011) The human Suv3 helicase interacts with replication protein A and flap endonuclease 1 in the nucleus. Biochemical Journal, 440 . pp. 293-300. ISSN 1042-0991
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Abstract
The human Suv3 helicase has been shown to be a major player in mitochondrial RNA surveillance and decay. In the present study we identify two new interaction partners of hSUV3: the RPA (replication protein A0 and FEN1 (flap endonuclease). Another single-strand-binding protein, mtSSB fails to affect hSUV3 activity. Flap endonuclease activity of FEN1 is stimulated by hSUV3 independenttly of flap length. SUV3 may play a significant role in nuclear DNA metabolism.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > QH Natural history > QH426 Genetics Q Science > QR Microbiology |
| Divisions: | Institute of Genetics and Biotechnology UW |
| ID Code: | 234 |
| Deposited By: | Prof. dr hab. Piotr P. Stepien |
| Deposited On: | 13 Mar 2012 09:54 |
| Last Modified: | 28 Mar 2012 20:36 |
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