Compartmentalization during bacterial spore formation

Abstract

Here, we explore the recent advancements in understanding cellular compartmentalization during bacterial spore formation, primarily focusing on the model organism Bacillus subtilis. The hallmark of sporulation, asymmetric septation, physically separates the mother cell and forespore, enabling distinct developmental fates. We highlight the role of the asymmetric septum as an organizational hub coordinating diverse compartmentalized functions — from gene regulation to metabolism and protein synthesis machinery localization.