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[(,)-167.3(2)0(0)13.6(0)13.1(4\))12.7(,)-173.6(a)-170.2(de)16.1(ri)21.1(va)18.7(ti)15(ve)-165(of)-167.6(t)12.2(h)0(e)-167.7(S)0(h)17.1(i)0(g)17.3(a)-170.2(to)15.7(xi)19.6(n)]TJ
-10.5529 -1.2203 TD
[(co)16.9(nv)14.8(e)12.8(r)0(t)11.5(i)0(n)18.4(g)-270(ph)14.2(a)13.1(g)0(e)-263.6(9)0(3)19.9(3)0(W)14.1(,)-268.5(wh)14(ic)16.2(h)-268.9(w)0(a)17.8(s)-273.2(de)16.1(vo)21.8(id)-265.8(of)-262.5(t)12.2(h)0(e)-268.8(t)12.2(ox)14(in)-259.8(ge)14.7(ne)15.7(s)]TJ
0 -1.2267 TD
[(fo)15.7(r)-241(s)0(a)18.1(f)12.2(et)12.3(y)-238.4(r)0(e)18.4(a)0(s)18.1(o)0(n)12.8(s)0(,)-225.5(b)0(u)13.2(t)-240.7(re)18.4(t)12.2(a)0(i)15.9(n)0(e)15.7(d)-236.9(al)15.9(l)-237.5(o)0(t)15.7(h)0(e)15.7(r)-241(f)12.2(e)0(a)13.2(t)12.2(ur)16.9(es)-235.2(of)-230.9(t)12.2(h)0(i)12.1(s)-235.3(ph)14.2(ag)21.4(e.)]TJ
/F13 1 Tf
0 -2.4406 TD
[(Media)-334.3(and)-335.7(growth)-331.5(conditions)]TJ
/F5 1 Tf
1.1128 -1.8336 TD
[(Ei)18.8(t)12.2(h)0(e)15.7(r)-607.7(1/)16.5(1)13.1(5)0(-)19(L)0(u)20.9(r)0(i)14.7(a)13.1(-B)15.5(e)12.8(r)0(t)17.8(a)13.1(ni)-601.3(\(L)15.5(B\))-604.1(m)15.1(e)0(d)16.1(i)0(u)20.4(m)-610.9(\()12.2(S)0(a)14.7(m)15.1(br)13.9(oo)19.7(k)-611.4(a)13.1(nd)]TJ
-1.1128 -1.2203 TD
[(Ru)19.7(ss)16.3(e)12.8(l)0(l)18.2(,)-205.2(20)19.9(01)19.9(\))-209.1(w)0(i)20.1(t)0(h)-199.9(1)13.1(5-)19(fo)15.7(ld)-196.2(le)21.9(ss)-198.6(co)16.9(nc)22.6(en)15.7(t)12.2(r)0(a)18.8(t)0(i)15(o)0(n)19.1(s)-203.6(of)-199.3(nu)20.5(tr)17.8(ie)15.5(nt)21.4(s,)-200.2(t)12.2(h)0(a)16.1(t)]TJ
0 -1.2267 TD
[(is)20.4(,)-224.2(0)0(.)16.5(3)13.1(3)-157.6(g)-225.7(y)14.6(e)0(a)19.6(s)0(t)-216.8(e)0(x)16.9(t)12.2(ra)18.8(ct)-214.7(an)16.1(d)-218(0)0(.)16.5(6)13.1(7)-227.1(b)14.6(ac)13.9(t)12.2(o)0(-)15.7(p)0(e)24(p)0(t)17.1(o)0(n)19.1(e)0(/)16.1(L)0(,)-214.6(a)13.1(nd)-215(st)17.2(a)13.1(n)0(d)18.9(a)0(r)18.8(d)]TJ
0 -1.2203 TD
[(am)21.9(ou)14.8(nt)-553.9(\(1)19(0)-157.6(g)0(/)17.9(L)0(\))-553.6(o)0(f)-559.7(N)12.7(aC)19.3(l)-566.3(o)0(r)-553.6(a)-568.6(mi)17.9(ni)24.7(ma)15.6(l)-566.3(m)15.1(ed)16.1(iu)20.4(m)-566.6(M)13.9(MG)15.1(lu)]TJ
T*
[(\()-114.3(J)0(a)19(s)0(i)14.1(e)12.7(ck)21.6(i)-231.2(a)0(n)16.1(d)-224.3(W)]TJ
/F12 1 Tf
6.7339 0 TD
(e)Tj
.0632 0 TD
()Tj
/F5 1 Tf
.3604 0 TD
[(gr)20.2(zy)15(n,)-215(20)19.9(03)19.9(\))-234.4(w)0(e)23.8(r)0(e)-221.9(u)0(s)16.3(e)12.8(d.)-220.9(In)-220.5(so)21.2(me)-218.8(ex)16.9(pe)17.7(ri)21.1(me)21.5(nt)15.1(s,)]TJ
-7.1575 -1.2266 TD
[(Or)21.5(sa)18.1(li)18.2(t)-177.5(\()0(I)16.4(B)0(S)17.5(S)-175.5(Bi)18.8(om)18.6(ed)-173.6(C)12.5(o)0(.)19.6(,)-180(C)12.5(r)0(a)18.8(c)0(o)16.9(w)0(,)-168.9(P)0(o)21.2(l)0(a)15.9(n)0(d)18.9(\))12.2(,)-180(a)13.1(n)-180.4(o)0(r)15.5(a)13.1(l)-180.6(r)0(e)18.4(h)0(y)17.5(d)0(r)21.6(a)0(t)19(i)0(o)19(n)]TJ
0 -1.2203 TD
[(mi)17.9(xt)22.7(ur)16.9(e)-278.1(w)0(i)20.1(t)12.2(h)-275.3(d)0(e)16.1(c)13.4(re)18.4(as)18.1(e)12.7(d)-274.9(os)14.9(mo)18.6(la)22.3(ri)21.1(ty)20.4(,)-274.8(w)0(a)17.8(s)-273.2(ad)16.5(de)22.4(d)-274.9(t)0(o)-268.8(c)13.4(ul)14.1(t)12.2(u)0(r)16.9(e)-271.8(me)15.2(-)]TJ
T*
[(di)18.8(um)-485.8(at)-493.2(t)12.2(h)0(e)-490.1(a)0(m)21.9(o)0(u)14.8(n)0(t)-490.7(o)0(f)-490.1(2)13.1(.2)-147.9(g)-497.6(p)0(e)17.7(r)-500.2(1)13.1(0)0(0)-144.4(m)0(L)-487.4(\()0(e)12.3(q)14.6(ua)18.1(l)-496.7(t)0(o)-490.1(t)0(h)15.1(e)-499.4(re)18.4(-)]TJ
0 -1.2266 TD
[(co)16.9(mm)23.8(en)15.7(de)22.4(d)-173.7(d)0(o)19.5(s)0(e)-159.3(f)0(o)15.7(r)-171.4(pa)18.1(t)12.2(i)0(e)21.9(n)0(t)15.1(s)0(\))17.2(.)-167.3(Th)18.9(e)-170.6(c)0(o)16.9(n)0(c)16.3(e)12.8(nt)15.1(ra)25.1(ti)15(on)19.1(s)-172(o)0(f)-161.3(p)0(a)18.1(r)0(t)24.1(i)0(c)16.2(u)0(l)20.4(a)0(r)]TJ
0 -1.2203 TD
[(Or)21.5(sa)18.1(li)18.2(t)12.2()0(s)-167.6(c)0(o)16.9(m)15.1(po)14.8(un)20.6(ds)-162.4(in)-165(su)16.3(ch)-167.1(a)-170.2(m)0(e)21.5(d)0(i)18.8(u)0(m)-163.3(w)0(e)17.4(r)0(e)-165(a)13.1(s)-178.4(f)12.2(ol)19(lo)19(ws)16(:)-173.6(1)13.1(3.)16.5(5)-151.3(g)0(/)]TJ
T*
[(L)-559.4(\()12.2(75)-150.8(m)15.1(M)0(\))-549.4(g)0(l)17.3(u)0(c)18.3(o)0(s)21.2(e)0(,)-552.9(1)13.1(.7)-147.9(g/)17.9(L)-553.1(\()0(7)19(5)-157.6(mM)16.3(\))-556.9(s)0(o)21.2(d)0(i)18.8(u)0(m)-549(i)0(o)19(n)0(s)20.6(,)-559.3(2.)16.5(3)-151.3(g)0(/)17.9(L)]TJ
T*
[(\(6)19(5)-157.6(m)0(M)22.6(\))-512.6(c)13.4(h)0(l)18.4(o)0(r)21.8(i)0(d)18.8(e)0(,)-502.3(0)13.1(.8)-147.9(g/)24.2(L)-508.8(\()0(2)19(0)-157.6(mM)22.6(\))-512.6(p)0(o)21.2(t)12.2(as)18.1(si)20.4(um)-498.4(io)19(ns)20.6(,)-508.7(1)0(.)16.5(9)-151.3(g/)17.9(L)]TJ
0 -1.2266 TD
[(\(1)19(0)-157.6(m)0(M)22.6(\))-209.1(c)13.4(i)0(t)15(r)0(a)18.8(t)12.2(e;)-198.8(t)12.2(h)0(e)-193(o)0(s)14.9(m)0(o)18.6(l)0(a)22.2(r)0(i)21.1(t)0(y)-194.6(o)0(f)-199.3(t)12.2(he)-199.3(so)21.2(lu)14.1(t)12.2(i)0(o)19(n)-205.7(wa)17.8(s)-203.6(2)13.1(45)-195(mO)18.4(sm)20.1(/)]TJ
0 -1.2203 TD
[(L.)-189.3(Ba)22.8(ct)12.9(e)12.8(r)0(i)21.1(a)-201.8(we)17.4(re)-184(cu)18.3(lt)15(ur)23.2(ed)-192.6(a)13.1(t)-202.8(3)13.1(7)]TJ
/F10 1 Tf
12.8039 0 TD
()Tj
/F5 1 Tf
.3857 0 TD
[(C)-196.2(i)0(n)-190.3(s)0(h)20.6(a)0(k)15(e)-195.9(a)16.5(sk)19.6(s)-197.3(w)0(i)20.1(t)0(h)-193.5(a)13.1(gi)17.3(t)12.2(a)0(t)19(i)0(o)19(n)0(.)]TJ
-13.1896 -1.2203 TD
[(Is)15.5(ol)25.3(eu)17.7(ci)16.2(ne)-344.7(st)17.2(ar)18.8(va)18.7(t)12.2(i)0(o)19(n)-357.5(of)-351(b)14.6(a)0(c)13.9(t)12.2(er)18.4(ia)-344.5(gr)20.2(ow)14.6(in)18.4(g)-352.2(i)0(n)-348.4(t)0(h)15.1(e)-354(MM)21.4(Gl)16.7(u)-355.4(m)0(e)15.2(-)]TJ
0 -1.2267 TD
[(di)18.8(um)-340.4(wa)17.8(s)-355.4(i)0(n)18.4(d)0(u)20.9(c)0(e)19.8(d)-357.1(b)14.6(y)-352.2(ad)16.5(di)18.8(t)12.2(i)0(o)19(n)-357.5(of)]TJ
/F15 1 Tf
15.2572 0 TD
(l)Tj
/F5 1 Tf
.4932 0 TD
.3447 Tc
[(-)356.9(v)344.7(a)363.4(l)344.7(i)362.9(n)344.7(et)344.7(oa)-8.9()344.7(n)363.6(a)357.8(l)-12.9(c)358.1(o)344.7(n)363.8(c)344.7(e)358.2(n)344.7(-)]TJ
12.2475 74.5598 TD
0 Tc
[(tr)17.8(at)19(io)19(n)-376.4(o)0(f)-363.6(1)-157.6(mg)23.3(/m)18.4(L.)-366.3(Th)18.9(e)-372.9(p)0(H)-361.7(v)0(a)18.7(l)0(u)20.4(e)-373(of)-363.6(al)15.9(l)-370.3(v)0(a)18.7(r)0(i)21.1(a)0(n)16.1(t)12.2(s)-374.4(o)0(f)-363.6(L)0(B)-366.4(a)13.1(nd)]TJ
0 -1.2203 TD
[(MM)15.1(G)13.9(l)0(u)-264.1(w)0(a)17.8(s)-266.9(7.)16.5(2)13.1(.)]TJ
/F13 1 Tf
0 -2.447 TD
[(Monitoring)-339.5(of)-330.4(phage)-338.2(development)]TJ
0 -1.2203 TD
[(after)-334.2(prophage)-336.5(induction)]TJ
/F5 1 Tf
1.1128 -1.8336 TD
[(Lyso)20.1(gen)11.3(ic)-179.9(bac)15.8(ter)11.6(ia)-180.1(were)-172.8(cul)14.8(ture)16.5(d)-186.4(i)0(n)-184(i)0(n)12.1(dic)13.1(ate)12.8(d)-186.4(med)18.5(ium)-179.5(to)-180.3(an)]TJ
/F6 1 Tf
-1.1128 -1.2266 TD
(A)Tj
/F5 1 Tf
6.7246 0 0 5.9768 319.4645 653.0455 Tm
(600)Tj
8.9663 0 0 8.9663 332.0503 654.5195 Tm
[(of)-281.4(0.1)17(.)-287.4(Pro)14.1(pha)14.7(ge)-282.5(ind)15.4(uct)11.5(ion)-275.3(was)-280.7(pro)14.1(vok)17.4(ed)-281.1(by)-280.7(add)13.5(iti)17.8(on)-284.4(of)]TJ
-2.1182 -1.2203 TD
[(mito)14.6(myc)17.7(in)-291.5(C)-291(t)0(o)-294.1(a)-290.4(na)13.1(l)-294.4(con)13.5(cent)15.9(ra)12.4(tio)12.2(n)-294.2(o)0(f)-294.1(1)]TJ
/F11 1 Tf
18.1847 0 TD
(l)Tj
/F5 1 Tf
.5501 0 TD
[(g/m)14(L.)-284.1(Samp)15.7(les)-282.9(of)]TJ
-18.7348 -1.2203 TD
[(the)-174.5(cu)12(ltu)13.6(re)-177.6(wer)16.7(e)-176.9(wit)13.3(hdr)11.9(awn)-168.9(at)-177(in)12.1(di)12.4(cat)13.4(ed)-173.6(time)17.5(s.)-175(To)-170.2(eac)14(h)-180.4(sam)14.3(ple)]TJ
T*
[(\(vol)17.8(ume)-315(of)-313.1(0.5)-153.7(mL\))11.6(,)-319.1(3)0(0)]TJ
/F11 1 Tf
10.0345 0 TD
(l)Tj
/F5 1 Tf
.5438 0 TD
[(L)-319.1(o)0(f)-319.4(chl)12.8(oro)12.7(for)15(m)-320(was)-312.3(add)13.5(ed,)-309.3(and)-309.4(fol)12.2(-)]TJ
-10.5782 -1.2266 TD
[(lowi)13.8(ng)-292.3(vort)14.3(exi)13.4(ng)-292.3(for)-294.8(20)-157.1(sec)12.1(,)-300.1(the)-294.6(mix)15.7(ture)-287(was)-293.3(cent)15.9(rif)14.3(uge)13.3(d)-300.2(i)0(n)-297.8(a)]TJ
0 -1.2203 TD
[(mic)12.3(rof)15(uge)-252.3(\(20)13.2(00)]TJ
/F6 1 Tf
7.2461 0 TD
(g)Tj
/F5 1 Tf
.7587 0 TD
[(for)-256.9(5)-157.6(min)14.5(\).)-256.3(The)-252.9(lysa)16.5(te)-259.6(was)-249.1(tit)14.5(rat)12(ed)-255.8(on)]TJ
/F6 1 Tf
16.1866 0 TD
[(E.)-252.5(col)12.8(i)]TJ
/F5 1 Tf
-24.1915 -1.2203 TD
[(C60)13.5(0)-555.9(str)16.5(ain)-550.2(\(Sa)14.2(mbr)16.3(ook)-547.4(and)-543.3(Rus)12.1(se)11.4(ll,)-547.4(20)13.6(01\))-549.6(by)-546.3(the)-547.5(pla)14.6(tin)11.6(g)]TJ
0 -1.2266 TD
[(meth)17.7(od,)-173.1(wh)14(ich)-170.6(all)12.4(ows)-163.8(to)-174(obt)11.3(ain)-170.8(wel)13.9(l-v)14.2(isi)16.9(ble)-172.2(pl)14.1(aqu)13.7(es)-171.9(of)-174(phag)16.6(es)11.4(,)]TJ
0 -1.2203 TD
[(whic)17.5(h)-205.7(oth)12.3(er)12(wis)12.5(e)-202.2(for)15(m)-206.2(v)0(e)12(r)0(y)-194.8(sma)14.3(ll)-196.8(one)12.9(s,)-200.2(in)12(clu)14.8(ding)-191.4(99)13.6(3W)-200.9(and)-189.3(its)]TJ
T*
[(deri)18.2(vat)11.9(ive)14.8(s,)-269.8(as)-272.7(prev)16.3(io)12.7(usl)12.8(y)-276.3(des)14.8(cri)15.5(bed)-266.6(\()]TJ
/F9 1 Tf
16.193 0 TD
(q)Tj
/F5 1 Tf
.5564 0 TD
(os)Tj
.588 .0506 TD
()Tj
/F6 1 Tf
.6386 -.0506 TD
[(et)-273.1(al)11.5(.)]TJ
/F5 1 Tf
1.9222 0 TD
[(,)-274.8(2)0(0)13.6(08\))13.2(.)]TJ
/F13 1 Tf
-19.8982 -2.447 TD
[(Estimation)-278.9(of)-279.8(phage)-275(and)-272.5(bacterial)-276(DNA)-275.4(content)-277.2(in)-279.6(cells)]TJ
/F5 1 Tf
1.1128 -1.8336 TD
[(Bacteria)-341(were)-337.2(cultured)-344.7(as)-335.9(described)-337.5(in)-342(the)-338.9(preceding)-337.9(par-)]TJ
-1.1128 -1.2203 TD
[(agraph.)-226.8(At)-229.5(indicated)-224.3(times)-224.1(after)-228.7(prophage)-228.4(induction,)-226(samples)]TJ
T*
[(\(1)-170.7(mL)-196.6(each\))-204.9(were)-204.5(withdrawn)-200.6(and)-201.9(boiled)-200.5(for)-200(10)-169.7(min.)-197.1(Following)]TJ
0 -1.2266 TD
[(centrifugation)-339.3(\(4000)]TJ
/F6 1 Tf
9.1366 0 TD
(g)Tj
/F5 1 Tf
.822 0 TD
[(for)-332.7(10)-163.4(min\),)-330.3(supernatants)-328.8(\(1.5)]TJ
/F11 1 Tf
13.1011 0 TD
(l)Tj
/F5 1 Tf
.5564 0 TD
[(L)-325.5(from)]TJ
-23.6161 -1.2203 TD
[(each)-299.3(sample\))-300.8(were)-299.3(used)-296.4(as)-298(the)-300.9(source)-296.2(of)-300.4(templates)-301.2(for)-294.8(quan-)]TJ
T*
[(titative)-659.9(polymerase)-662.2(chain)-654(reaction)-660.8(\(PCR\).)-660.9(The)-657.5(following)]TJ
0 -1.2266 TD
[(primers)-365.5(were)-362.5(used)-366(\(concentration)-367.1(of)-363.6(each)-362.5(primer)-364.2(stock)-362.3(was)]TJ
0 -1.2203 TD
[(600)-245.1(nM,)-239(and)-246.2(the)-237.7(volume)-246.1(of)-243.5(each)-242.4(primer)-244(solution)-246.8(added)-236(to)-243.5(the)]TJ
T*
[(reaction)-224.5(mixture)-220.7(was)-217.4(1.5)]TJ
/F11 1 Tf
10.7679 0 TD
(l)Tj
/F5 1 Tf
.5564 0 TD
[(L\):)-215(for)-218.9(determination)-226.8(of)-218.2(the)-218.7(amount)]TJ
-11.3243 -1.2266 TD
[(of)-294.1(phage)-293.1(933W)]TJ
/F14 1 Tf
6.6327 0 TD
(D)Tj
/F5 1 Tf
.6702 0 TD
[(tox)-289.9(DNA,)-290.2(phageF)-291.2(\(5)]TJ
/F10 1 Tf
8.9153 0 TD
()Tj
/F5 1 Tf
.2529 0 TD
[(-CAG)-291.6(GGG)-287.1(GAC)-291.2(ACA)]TJ
-16.4712 -1.2203 TD
[(AAA)-314(GAC)-316.5(AC\))-311.9(and)-309.4(phageR)-316.3(\(5)]TJ
/F10 1 Tf
13.765 0 TD
()Tj
/F5 1 Tf
.2466 0 TD
[(-GCC)-315.7(CAT)-308.1(GAC)-310.1(AGG)-315(AAG)]TJ
-14.0116 -1.2203 TD
[(TTG)-320.9(TT\)complementary)-325.7(to)-319.4(the)-319.9(fragment)-322.6(comprising)-321.4(parts)]TJ
0 -1.2266 TD
[(of)-294.1(the)]TJ
/F6 1 Tf
2.8074 0 TD
(O)Tj
/F5 1 Tf
1.0622 0 TD
(and)Tj
/F6 1 Tf
1.9664 0 TD
(P)Tj
/F5 1 Tf
.8915 0 TD
[(genes;)-290(for)-294.8(determination)-296.3(of)-287.8(bacterial)-289.1(genomic)]TJ
-6.7276 -1.2203 TD
[(DNA,)-277.6(bacterialF)-280.8(\(5)]TJ
/F10 1 Tf
8.2704 0 TD
()Tj
/F5 1 Tf
.2466 0 TD
[(-CAA)-281.6(GAG)-277.1(TTT)-274.6(GAT)-275(CCT)-275.2(GGC)-275.9(TCA)-276.4(G\))]TJ
-8.517 -1.2203 TD
[(and)-556(bacterialR)-558.9(\(5)]TJ
/F10 1 Tf
8.0048 0 TD
()Tj
/F5 1 Tf
.2529 0 TD
[(-CAT)-555.1(ACG)-550.4(GCT)-558.3(ACC)-551.8(TTG)-554.9(TTA)-557.5(CGA)]TJ
-8.2577 -1.2203 TD
[(CTT\)complementary)-231(to)-230.9(the)-225.1(fragment)-227.7(of)-224.5(the)-225.1(gene)-228.9(coding)-225(for)]TJ
0 -1.2266 TD
[(16S)-231.5(RNA.)-236.2(After)-236.9(initial)-232.5(denaturation)-233(\(94)]TJ
/F10 1 Tf
16.9644 0 TD
()Tj
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T*
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T*
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[(glucose)-291.5(a)-.3(t)-285.7(a)-291.1(concentration)-288.7(o)-3.5(f)-285.7(1)-.3(.6%)-286.9(r)-1.4(ev)4.8(ersed)-282(t)-1.2(he)-285.2(effect)-285.7(of)-292.1(cit-)]TJ
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[(Citrate-mediated)-341.3(inhibition)-336(of)-330.4(phage)-331.9(933W)]TJ
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28.0042 16.5091 TD
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T*
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T*
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T*
[(that)-361.9(citr)4.6(ate-mediated)-358.1(inhibit)11.6(i)-11.4(on)-364.8(of)-361.9(phage)-361.3(933)11.6(W)]TJ
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(D)Tj
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[(t)-13.1(o)-15.4(x)-368.9(d)-15.7(ev)-19.6(e)-12.5(l)-9.9(-)]TJ
-22.1302 -1.2267 TD
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[(Amino)-334.1(acid)-334.1(starvation)-332.7(prevents)-332.2(phage)]TJ
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[(tox)-336.3(development)]TJ
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-1.1128 -1.2203 TD
[(experience)-427.3(conditions)-434.4(of)-426.9(transient)-430(starvation,)-432.6(and)-423.2(previous)]TJ
ET
q
227.007 0 0 289.757 317.083 442.488 cm
/Im1 Do
Q
BT
/F16 1 Tf
8.9663 0 0 8.9663 310.8472 425.707 Tm
[(FIG.)-539.1(1.)]TJ
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[(Development)-542(of)-540.7(bacteriophage)-544(933W)]TJ
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[(tox)-536.5(in)]TJ
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(Es-)Tj
-25.3549 -1.1065 TD
[(cherichia)-810.1(coli)]TJ
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[(CF1648)-812(\(wild-type\))-815.9(host)-811(in)-816.3(the)-806.8(presence)]TJ
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T*
[(duction)-519.6(with)-514.9(mitomycin)-524.7(C)-512.3(\()0(1)]TJ
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[(g/mL\))-520.6(at)-512.1(time)-519.9(0.)-520.9(Panel)]TJ
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(A)Tj
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[(shows)-434.1(normalized)-430.7(numbers)-438.6(of)-433.2(pfu/mL)-430.4(of)-433.2(the)-433.7(culture,)-433.2(cal-)]TJ
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[(culated)-557.1(by)-552.6(subtraction)-561(of)-553.3(the)-553.8(pfu/mL)-556.8(values)-556.4(in)-557(cultures)]TJ
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[(untreated)-527.2(with)-533.8(mitomycin)-524.7(C)-531.3(from)-526.3(the)-528.6(pfu/mL)-531.6(values)-524.8(in)]TJ
T*
[(mitomycin)-505.7(Ctreated)-509.5(cultures.)-504(Average)-512.4(values)-505.9(from)-501(three)]TJ
T*
[(independent)-388(experiments)-383.2(are)-379.5(presented,)-385.9(with)-382.1(error)-384.1(bars)-379(in-)]TJ
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[(at)-569(times)-571.8(90,)-571(120,)-570.5(150,)-570.5(and)-568.6(180)-169.3(min.)-570.1(Panel)]TJ
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(600)Tj
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(600)Tj
8.9663 0 0 8.9663 337.7763 316.1196 Tm
[(\))-537.9(values)-543.8(of)-540.7(bacterial)-542(cultures)-545.4(either)-545.3(treated)-541.4(\(closed)]TJ
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T*
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[(were)-236.1(signicantly)-238.4(different)-245.8(\()]TJ
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[(INHIBITION)-337.6(OF)-337.5(STX)-330.3(PHAGE)-339.6(DEVELOPMENT)]TJ
53.5677 0 TD
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