Karkusiewicz, Iwona and Rempola, Bozenna and Gromadka, Robert and Grynberg, Marcin and Rytka, Joanna (2004) Functional and physical interactions of Faf1p, a Saccharomyces cerevisiae nucleolar protein. Biochemical and biophysical research communications, 319 (2). pp. 349-57. ISSN 0006-291X
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Abstract
We report the discovery and characterisation of a novel nucleolar protein of Saccharomyces cerevisiae. We identified this protein encoded by ORF YIL019w, designated in SGD base as Faf1p, in a two hybrid interaction screen using the known nucleolar protein Krr1 as bait. The presented data indicate that depletion of the Faf1 protein has an impact on the 40S ribosomal subunit biogenesis resulting from a decrease in the production of 18S rRNA. The primary defect is apparently due to inefficient processing of 35S rRNA at the A(0), A(1), and A(2) cleavage sites.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > QR Microbiology |
| Divisions: | Laboratory of DNA Sequencing and Oligonucleotide Synthesis |
| ID Code: | 36 |
| Deposited By: | Robert Gromadka |
| Deposited On: | 03 Apr 2013 09:03 |
| Last Modified: | 03 Apr 2013 09:03 |
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