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Altering the fungal cell wall integrity and practical aspects of these modifications

Kruszewska, Joanna S. and Piłsyk, Sebastian (2013) Altering the fungal cell wall integrity and practical aspects of these modifications. In: The fungal cell wall. Nova Science Publishers, Inc.. ISBN 978-1-62618-229-5 (In Press)

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In this chapter we compare the cell wall structure of filamentous fungi and the yeast Saccharomyces cerevisiae. The genetic engineering of the cell wall of Trichoderma, Aspergillus, Neurospora, S. cerevisiae, Schizosaccharomyces pombe, Hansenula polymorpha, Kluyveromyces and others is discussed and the consequences of direct changes in the synthesis of cell wall components, especially those affecting protein production and secretion by the mutants and their sensitivity to antifungal agents are highlighted. Furthermore, we discuss the close correlation between the cell wall structure and the activity of enzymes engaged in protein glycosylation and in the biosynthesis of glycosylphosphatidylinositol anchors. We also show problems with stability of the generated changes in the cell wall structure, which are detected and often overcome by cell wall compensatory mechanisms.

Item Type:Book Section
Subjects:Q Science > QH Natural history > QH301 Biology
Divisions:Laboratory of Fungal Glycobiology
ID Code:370
Deposited By: prof dr hab Joanna S. Kruszewska
Deposited On:29 Nov 2012 15:17
Last Modified:17 Oct 2014 12:53

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