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Complex formation of fenchone with alpha-cyclodextrin: NMR titrations

Nowakowski, Michał and Ejchart, Andrzej (2014) Complex formation of fenchone with alpha-cyclodextrin: NMR titrations. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 79 . pp. 337-342. ISSN 1573-1111 (electronic version)

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13C NMR titration studies of inclusion complexes of bicyclic terpenoid, fenchone enantiomers with acyclodextrin revealed their 1:2 guest–host stoichiometry. Sequential binding constants were determined indicating a strong binding cooperativity of two a-cyclodextrin to fenchone. The overall association constants were used to calculate the Gibbs free energies of diastereomeric complex formation, which might be used as a measure of chiral recognition of fenchone by a-cyclodextrin. These results were compared with corresponding data derived for camphor, which is an isomeric bicyclic terpenoid.

Item Type:Article
Additional Information:This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited
Subjects:Q Science > QD Chemistry
Divisions:NMR Laboratory
ID Code:724
Deposited By: professor Andrzej Ejchart
Deposited On:07 Jul 2014 11:51
Last Modified:04 Nov 2014 08:47

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