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Hypophosphatemia and sudden infant death syndrome (SIDS)--is ATP the link?

Szczesny, Pawel and Poznański, Jarosław and Paczek, Leszek and Zielenkiewicz, Piotr (2014) Hypophosphatemia and sudden infant death syndrome (SIDS)--is ATP the link? Informa Healthcare.

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Official URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC391671...


In their recent letter Van Kempen and co-workers presented an intriguing hypothesis linking hypophosphatemia and sudden infant death syndrome (SIDS) (1), founded on the work by Siren and Siren on the critical diaphragm failure being the cause of SIDS incidences (2,3). Van Kempen and co-workers argued that both etiology and symptoms of SIDS can be explained by low concentrations in erythrocytes of phosphate metabolites, mainly 2,3-biphosphoglycerate (2,3-BPG, also known as 2,3-diphosphoglycerate, 2,3-DPG), which in effect would impair muscle function (especially diaphragm) and lead to respiratory failure as Siren and Siren originally stated. We find the hypothesis interesting and definitely worth further investigation; however, we would assign the main role to ATP, not to 2,3-BPG.

Item Type:Other
Additional Information:Letter to the Editor Ups J Med Sci. Mar 2014; 119(1): 55–56.
Subjects:R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Divisions:Department of Bioinformatics
Department of Biophysics
ID Code:727
Deposited By: Prof Jaroslaw Poznanski
Deposited On:01 Dec 2014 10:04
Last Modified:11 Dec 2014 13:18

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