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Effects of liposomes with polyisoprenoids, potential drug carriers,on the cardiovascular and excretory system in rats

Gawrys, Olga and Polkowska, Marta and Roszkowska-Chojecka, Malwina and Gawarecka, Katarzyna and Chojnacki, Tadeusz and Swiezewska, Ewa and Masnyk, Marek and Chmielewski, Marek and Rafałowska, Janina and Kompanowska-Jezierska, Elżbieta (2014) Effects of liposomes with polyisoprenoids, potential drug carriers,on the cardiovascular and excretory system in rats. Pharmacological reports : PR, 66 (2). pp. 273-278. ISSN 1734-1140

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Abstract

Background: The unpredictable side effects of a majority currently used drugs are the substantial issue, in which patients and physicians are forced to deal with. Augmenting the therapeutic efficacy of drugsmay prove more fruitful than searching for the new ones. Since recent studies show that new cationic derivatives of polyisoprenoid alcohols (APrens) might exhibit augmenting properties, we intend to use them as a component of liposomal drug carriers. In this study we investigate if these compounds do not per se cause untoward effects on the living organism. Methods: Male Sprague–Dawley rats received for four weeks daily injections (0.5 ml sc) of liposomes built of dioleoyl phosphatidylethanolamine (DOPE), liposomes built of DOPE and APren-7 (ratio 10:1) or water solvent. Weekly, rats were observed in metabolic cages (24 h); blood and urine were sampled for analysis; body weight (BW) and systolic blood pressure (SBP) were determined. After chronic experiment, kidneys and heart were harvested for histological and morphometric analysis. Results: The 4-week BW increments were in the range of 97 ± 4 to 102 ± 4%, intergroup differences were not significant. Microalbuminuria was the lowest in the group receiving liposomes with APren-7 (0.22 ± 0.03 mg/day). Water and food intake, plasma and urine parameters were similar in all groups. Conclusions: Newly designed liposomes containing APren-7 did not affect functions of the excretory and cardiovascular systems, and renal morphology; therefore we find them suitable as a component of liposomal drug carriers.

Item Type:Article
Subjects:Q Science > QH Natural history > QH301 Biology
Divisions:Department of Lipid Biochemistry
ID Code:752
Deposited By: Ewa Swiezewska
Deposited On:15 Oct 2014 14:57
Last Modified:01 Oct 2015 19:02

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