IBB PAS Repository

Virus-like particles as vaccine.

Chroboczek, Jadwiga and Szurgot, Inga and Szolajska, Ewa (2014) Virus-like particles as vaccine. Acta biochimica Polonica, 61 (3). pp. 531-9. ISSN 1734-154X


Official URL: http://www.actabp.pl/pdf/3_2014/531.pdf


This review presents data on commercial and experimental virus-like particle (VLP) vaccines, including description of VLP vaccines against influenza. Virus-like particles are multimeric, sometimes multiprotein nanostructures assembled from viral structural proteins and are devoid of any genetic material. VLPs present repetitive high-density displays of viral surface proteins. Importantly, they contain functional viral proteins responsible for cell penetration by the virus, ensuring efficient cell entry and thus tissue-specific targeting, determined by the origin of the virus. The foremost application of VLPs is in vaccinology, where they provide delivery systems that combine good safety profiles with strong immunogenicity and constitute a safe alternative to inactivated infectious viruses. These stable and versatile nanoparticles display excellent adjuvant properties capable of inducing innate and cognate immune responses. They present both, high-density B-cell epitopes, for antibody production and intracellular T- cell epitopes, thus inducing, respectively, potent humoral and cellular immune responses. Uptake of VLPs by antigen-presenting cells leads to efficient immune responses resulting in control of pathogenic microorganisms.

Item Type:Article
Subjects:Q Science > QR Microbiology > QR180 Immunology
Q Science > QR Microbiology > QR355 Virology
Divisions:Department of Protein Biosynthesis
ID Code:806
Deposited By: dr Ewa/E Szolajska
Deposited On:13 Nov 2014 11:45
Last Modified:13 Nov 2014 11:45

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