IBB PAS Repository

Leptospirosis vaccines

Wang, Zhijun and Jin, Li and Węgrzyn, Alicja (2007) Leptospirosis vaccines. Microbial Cell Factories, 6 (1). p. 39. ISSN 1475-2859

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Official URL: http://dx.doi.org/10.1186/1475-2859-6-39

Abstract

Leptospirosis is a serious infection disease caused by pathogenic strains of the Leptospira spirochetes, which affects not only humans but also animals. It has long been expected to find an effective vaccine to prevent leptospirosis through immunization of high risk humans or animals. Although some leptospirosis vaccines have been obtained, the vaccination is relatively unsuccessful in clinical application despite decades of research and millions of dollars spent. In this review, the recent advancements of recombinant outer membrane protein (OMP) vaccines, lipopolysaccharide (LPS) vaccines, inactivated vaccines, attenuated vaccines and DNA vaccines against leptospirosis are reviewed. A comparison of these vaccines may lead to development of new potential methods to combat leptospirosis and facilitate the leptospirosis vaccine research. Moreover, a vaccine ontology database was built for the scientists working on the leptospirosis vaccines as a starting tool.

Item Type:Article
Subjects:Q Science > QH Natural history > QH426 Genetics
Q Science > QR Microbiology
R Medicine > RA Public aspects of medicine
Divisions:Laboratory of Molecular Biology (in Gdansk)
ID Code:937
Deposited By: PhD Piotr Golec
Deposited On:29 Sep 2015 13:18
Last Modified:29 Sep 2015 13:18

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