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Arteriovenous oscillations of the redox potential: Is the redox state influencing blood flow?

Poznański, Jarosław and Szczesny, Pawel and Pawlinski, Bartosz and Mazurek, Tomasz and Zielenkiewicz, Piotr and Gajewski, Zdzislaw and Paczek, Leszek (2016) Arteriovenous oscillations of the redox potential: Is the redox state influencing blood flow? Redox report : communications in free radical research, 22 (5). pp. 210-217. ISSN 1743-2928

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Official URL: http://www.tandfonline.com/doi/abs/10.1080/1351000...


OBJECTIVE Studies on the regulation of human blood flow revealed several modes of oscillations with frequencies ranging from 0.005 to 1 Hz. Several mechanisms were proposed that might influence these oscillations, such as the activity of vascular endothelium, the neurogenic activity of vessel wall, the intrinsic activity of vascular smooth muscle, respiration, and heartbeat. These studies relied typically on non-invasive techniques, for example, laser Doppler flowmetry. Oscillations of biochemical markers were rarely coupled to blood flow. METHODS The redox potential difference between the artery and the vein was measured by platinum electrodes placed in the parallel homonymous femoral artery and the femoral vein of ventilated anesthetized pigs. RESULTS Continuous measurement at 5 Hz sampling rate using a digital nanovoltmeter revealed fluctuating signals with three basic modes of oscillations: ∼ 1, ∼ 0.1 and ∼ 0.01 Hz. These signals clearly overlap with reported modes of oscillations in blood flow, suggesting coupling of the redox potential and blood flow. DISCUSSION The amplitude of the oscillations associated with heart action was significantly smaller than for the other two modes, despite the fact that heart action has the greatest influence on blood flow. This finding suggests that redox potential in blood might be not a derivative but either a mediator or an effector of the blood flow control system.

Item Type:Article
Subjects:Q Science > Q Science (General)
R Medicine > R Medicine (General)
Divisions:Department of Bioinformatics
Department of Biophysics
ID Code:1198
Deposited By: Prof Jaroslaw Poznanski
Deposited On:19 Jul 2016 10:30
Last Modified:08 Mar 2018 15:33

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