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Lactic acid bacteria — promising vaccine vectors: possibilities, limitations, doubts

Szatraj, Katarzyna and Szczepankowska, Agnieszka K. and Chmielewska-Jeznach, Magdalena (2017) Lactic acid bacteria — promising vaccine vectors: possibilities, limitations, doubts. Journal of Applied Microbiology, 123 (2). 325 -339. ISSN 13645072

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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/jam.134...


Gram-positive and nonpathogenic lactic acid bacteria (LAB) are considered to be promising candidates for the development of new, safe systems of heterologous protein expression. Additionally, many experiments have shown that specific systemic and mucosal immune responses against selected pathogens can be elicited using modified LAB strains. For that reason they could be a good replacement of classical, often pathogenic, attenuated carriers. This solution offers many advantages in comparison to systemic inoculation, as well as, from immunological and practical points of view. The development of efficient mucosal vaccines is nowadays a priority in modern vaccinology, together with improvement of immunization efficiency, monitoring of antigen production in vivo, determination of optimal dose for vaccination, strain selection and characterization.

Item Type:Article
Uncontrolled Keywords:lactic acid bacteria, live vector vaccines, oral administration, heterologous gene expression, gut microflora
Subjects:Q Science > QR Microbiology
R Medicine > RM Therapeutics. Pharmacology
Divisions:Department of Microbial Biochemistry
ID Code:1404
Deposited By: Dr Agnieszka K Szczepankowska
Deposited On:06 Nov 2017 10:23
Last Modified:04 Apr 2018 22:05

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