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His6, His13, and His14 residues in Aβ 1–40 peptide significantly and specifically affect oligomeric equilibria

Przygońska, Kaja and Pacewicz, Magdalena and Sadowska, Wiktoria and Poznański, Jarosław and Bal, Wojciech and Dadlez, Michal (2019) His6, His13, and His14 residues in Aβ 1–40 peptide significantly and specifically affect oligomeric equilibria. Scientific Reports, 9 (1). p. 9449. ISSN 2045-2322

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Official URL: https://www.nature.com/articles/s41598-019-45988-1

Abstract

Oligomers of Aβ peptide are implicated as the most probable causative agent in Alzheimer’s disease. However, their structural properties remain elusive due to the dynamic and heterogeneous character of oligomeric species coexisting in solution. Nevertheless, new approaches, mainly based on mass spectrometry, provide unique access to these different structural forms. Using these methods, we previously showed that the N-terminal, non-amyloidogenic region of Aβ is involved in the network of interactions specifically stabilizing oligomers. In the present study, we identified three histidine residues as active participants in this network. Detailed knowledge of the structural features that are potentially important for oligomer-mediated neurotoxicity is a prerequisite for the rational design of oligomerization modifiers.

Item Type:Article
Subjects:Q Science > QC Physics
Divisions:Mass Spectrometry Laboratory
ID Code:1728
Deposited By: Kaja Przygonska
Deposited On:16 Jul 2019 12:24
Last Modified:16 Jul 2019 12:24

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