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Plasma Trimethylamine-N-oxide following Cessation of L-carnitine Supplementation in Healthy Aged Women.

Samulak, Joanna J. and Sawicka, Angelika K. and Samborowska, Emilia and Olek, Robert A. (2019) Plasma Trimethylamine-N-oxide following Cessation of L-carnitine Supplementation in Healthy Aged Women. Nutrients, 11 (6). p. 1322. ISSN 2072-6643

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Official URL: http://doi.org/10.3390/nu11061322

Abstract

L-carnitine supplementation elevates plasma trimethylamine-N-oxide (TMAO), which may participate in atherosclerosis development by affecting cholesterol metabolism. The aim of the current study was to determine the effect of increased plasma TMAO on biochemical markers in the blood following cessation of L-carnitine supplementation. The follow-up measurements were performed on subjects who completed 24 weeks of L-carnitine or placebo supplementation protocol. Blood samples were taken after finishing the supplementation and then 4 and 12 months following the supplementation withdrawal. Four months after cessation of L-carnitine supplementation, plasma TMAO concentration reached a normal level which was stable for the following eight months. During this period, no modifications in serum lipid profile and circulating leukocyte count were noted. TMAO implications in health and disease is widely discussed. The results of this study demonstrate no adverse effects of elevated plasma TMAO, induced by L-carnitine, on the measured parameters at 4 and 12 months after withdrawal of supplementation.

Item Type:Article
Subjects:R Medicine > RZ Other systems of medicine
Divisions:Mass Spectrometry Laboratory
ID Code:1732
Deposited By: Emilia Samborowska
Deposited On:16 Jul 2019 12:30
Last Modified:16 Jul 2019 12:30

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