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Ferritins in Chordata: potential evolutionary trajectory marked by discrete selective pressures

Golan, Maciej and Piłsyk, Sebastian and Muszewska, Anna and Wawrzyniak, Agata (2020) Ferritins in Chordata: potential evolutionary trajectory marked by discrete selective pressures. BioEssays (e20002). ISSN 1521-1878

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Official URL: https://onlinelibrary.wiley.com/doi/pdf/10.1002/bi...


Ferritins (FTs) are iron storage proteins that are involved in managing iron-oxygen balance. In our work, we present a hypothesis on the putative effect of geological changes that have affected the evolution and radiation of ferritin proteins. Based on sequence analysis and phylogeny reconstruction, we hypothesize that two significant factors have been involved in the evolution of ferritin proteins: fluctuations of atmospheric oxygen concentrations, altering redox potential, and changing availability of water rich in bioavailable ferric ions. Fish, ancient amphibians, reptiles, and placental mammals developed the broadest repertoire of singular FTs, attributable embryonic growth in aquatic environments containing low oxygen levels and abundant forms of soluble iron. In contrast, oviparous land vertebrates, like reptiles and birds, that have developed in high oxygen levels and limited levels of environmental Fe2+exhibit a lower diversity of singular FTs, but display a broad repertoire of subfamilies, particularly notable in early reptiles.

Item Type:Article
Subjects:Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH426 Genetics
Divisions:Laboratory of Fungal Glycobiology
Department of Microbial Biochemistry
ID Code:1931
Deposited By: Dr Sebastian Piłsyk
Deposited On:08 Dec 2020 09:15
Last Modified:08 Dec 2020 12:42

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