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RNA polymerase III under control: repression and de-repression

Boguta, Magdalena and Graczyk, Damian (2011) RNA polymerase III under control: repression and de-repression. Trends in Biochemical Sciences, 36 (9). pp. 451-456.



The synthesis of tRNA by yeast RNA polymerase III (Pol III) is regulated in response to changing environmental conditions . This control is mediated by Maf1, the global negative regulator of Pol III transcription conserved from yeast to man. Details regarding the molecular basis of Pol III repression by Maf1 are now emerging from recently reported structural and biochemical data on Pol III and Maf1. Efficient Pol III transcription, following the shift of cells from a non-fermentable carbon source to glucose, requires phosphorylation of Maf1. One of the newly identified Maf1 kinases is the chromatin-bound casein kinase II (CK2). Current studies allowed us to propose an innovative mechanism of Pol III regulation. We suggest that CK2-mediated phosphorylation of Maf1, occurring directly on tDNA chromatin, controls Pol III recycling.

Item Type:Article
Subjects:Q Science > QH Natural history > QH301 Biology
Divisions:Department of Genetics
ID Code:337
Deposited By: profesor Magdalena Boguta
Deposited On:02 Jan 2013 12:46
Last Modified:17 Oct 2014 13:26

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