Ziemińska, Elżbieta and Stafiej, Aleksandra and Toczyłowska, Beata and Lazarewicz, Jerzy W (2012) Acute Cytotoxicity Evoked by Tetrabromobisphenol A in Primary Cultures of Rat Cerebellar Granule Cells Outweighs the Effects of Polychlorinated Biphenyls. Polish Journal of Environmental Studies .
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Abstract
The aim of this study was to identify, among selected environmental toxins, the substance with the highest in vitro toxicity to neurons combined with the most marked induction of calcium imbalance, oxidative stress and mitochondrial dysfunction. Exposure of primary cultures of rat cerebellar granule cells for 30 min to polychlorinated biphenyls (PCBs) or brominated flame retardants (BFRs) at concentrations of 10-50 �M identified tetrabromobisphenol A as the compound with the highest toxicity. At a concentration of 25 �M, apart from the moderate activation of 45Ca uptake, this BFR induced the most pronounced increase in intracellular Ca2+ concentration, depolarization of mitochondria, and activation of ROS production
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| ID Code: | 513 |
| Deposited By: | Pawel Szczesny |
| Deposited On: | 03 Apr 2013 09:01 |
| Last Modified: | 03 Apr 2013 09:01 |
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