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An introduction to DNA chips: principles, technology, applications and analysis

Gabig-Cimińska, Magdalena and Węgrzyn, Grzegorz (2001) An introduction to DNA chips: principles, technology, applications and analysis. Acta Biochimica Polonica, 48 . pp. 615-622.



This review describes the recently developed GeneChip technology that provides efficient access to genetic information using miniaturised, high-density arrays of DNA or oligonucleotide probes. Such microarrays are powerful tools to study the molecular basis of interactions on a scale that would be impossible using conventional analysis. The recent development of the microarray technology has greatly accelerated the investigation of gene regulation. Arrays are mostly used to identify which genes are turned on or off in a cell or tissue, and also to evaluate the extent of a gene�s expression under various conditions. Indeed, this technology has been successfully applied to investigate simultaneous expression of many thousands of genes and to the detection of mutations or polymorphisms, as well as for their mapping and sequencing.

Item Type:Article
Subjects:Q Science > Q Science (General)
Q Science > QH Natural history
Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH426 Genetics
R Medicine > R Medicine (General)
T Technology > T Technology (General)
Divisions:Laboratory of Molecular Biology (in Gdansk)
ID Code:1150
Deposited By: Prof. Magdalena Gabig-Cimińska
Deposited On:29 Feb 2016 15:19
Last Modified:29 Feb 2016 15:19

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